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Table 3 Details on bone marrow concentrates used in clinical studies

From: Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review

Type

Cell carrier

Harvest location

Amount harvested

Amount used

Reference

BMC

Collagen membrane

Ilium

27Ā ml

0.5-2.7ā€‰Ć—ā€‰106 cells

[40]

BMC

Collagen powder or hyaluronic acid membrane and platelet gel

Posterior iliac crest

60Ā ml

2Ā ml 10ā€‰Ć—ā€‰concentrated BM

[31-33,39] NCT02005861

BMC

Type I collagen scaffold

Iliac crest

60Ā ml

Ā 

[34]

BMC

Collagen membrane

Ipsilateral iliac crest

60Ā ml

4-6ā€‰Ć—ā€‰concentrated BM, CFU-F/ml 2,000-5,700

[35]

BMC

Collagen I/III membrane

Ilium

30Ā ml

Ā 

[36]

BMC

Protein matrix in collagen hydroxyapatite scaffold

Ā Ā Ā 

NCT01159899

BMC and ACy

INSTRUCT scaffold

Ā Ā Ā 

[37] NCT01041885

ATSVF

Collagen scaffold

Infrapatellar fat pad

5Ā cc

Ā 

NCT02090140

  1. ACy autologous chondrocyte, ATSVF adipose tissue stromal vascular fraction, BM bone marrow, BMC bone marrow concentrate, CFU-F colony-forming unit-fibroblasts