Fig. 5

Stereological counts of transplanted human oligodendrocyte progenitor cells migrating into the contralateral hemisphere. a Migratory patterns at two time points (6 weeks and 3 months) after transplantation in two brain regions (corpus callosum and deep cortex) in impact acceleration (IA) animals. b Migratory tendencies in the same two locations based on experimental history (IA versus sham) at 3 months post-transplantation. In (A), the difference in cell numbers between 6 weeks and 3 months is significant by t test (*P < 0.05) in both corpus callosum and deep cortex (layer 6); two-way analysis of variance (ANOVA) shows that there is interaction between time and location (that is, time tends to favor deep cortical over callosal location; P < 0.05). In (B), there are no differences in cell numbers between sham and IA-injured subjects in corpus callosum or deep cortex at 3 months post-transplantation. In both groups of subjects, there are more cells in corpus callosum than deep cortex by t test (P < 0.05). Two-way ANOVA shows that there is no interaction between experimental history and location (that is, injury does not seem to influence the location of cells in one site over the other). OPC, oligodendrocyte progenitor cell