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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Expression of Wnt and Notch signaling pathways in inflammatory bowel disease treated with mesenchymal stem cell transplantation: evaluation in a rat model

Fig. 6

Expression of canonical Wnt signaling-related genes in mesenchymal stem cell transplantation (MSCT) group compared with inflammatory bowel disease (IBD) rat model. a Wnt3a mRNA decreased expression in MSCT rats compared with IBD rats (P = 0.004). b Declined Fzd3 expression (P = 0.014). c Decreased GSK-3β mRNA expression in inflammation (P = 0.035) and recovery to normal level after MSCT. d Decreased expression of APC at 14 days (P = 0.034), increased to normal level at 28 days. e Lower β-catenin mRNA expression in MSCT rats (P <0.001). f No different expression of TCF4 between IBD group and normal group, and low expression in mesenchymal stem cells (MSCs) (P = 0.036). g High c-myc expression at 14 days (P <0.01) declined at 28 days (P = 0.024). h Reduced cyclin D expression in MSCT at 28 days (P = 0.02)

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Stem Cell Research & Therapy

ISSN: 1757-6512