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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria

Fig. 4

a Photomicrographs of liver tissue stained with hematoxylin and eosin. Original magnification × 1000; bars = 100 μm. Mice were inoculated with 5 × 106 parasitized RBCs or saline and treated with BM-MSCs. Livers were excised 5 days after infection. Note the intact hepatocytes (single black arrows) involving the centrolobular vein. Administration of BM-MSCs did not alter the liver architecture (double black arrows) or centrolobular vein in control mice. P. berghei-infected, saline-treated mice exhibited hepatocyte derangement (double white arrowhead), increased deposition of malaria pigment, and an increased number of Kupffer cells (single white arrows). BM-MSC therapy increased the number of regenerated hepatocytes and Kupffer cells (double white arrows). b A semiquantitative, severity-based score was used to measure malaria pigment deposition, inflammation, fibrosis, and histoarchitectural damage in livers of mice infected with P. berghei or mock-infected with saline and, 24 hours after infection, treated with BM-MSCs. Values are expressed as median (interquartile range) of six animals in each group. *Significantly different from uninfected group (p <0.05). +Significantly different from P. berghei-infected group (p <0.05). BM-MSC bone marrow-derived mesenchymal stromal cell, Sal saline

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