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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria

Fig. 7

a Photomicrographs of lung parenchyma stained with hematoxylin and eosin. Original magnification × 1000; bars = 100 μm. In uninfected mice treated or not with BM-MSCs, normal architecture was observed with intact alveolar–capillary barrier (black arrows and white arrows, respectively). P. berghei infection induced lung damage, associated with structural disarrangement, thickening of the alveolar–capillary barrier by mononuclear cells (double black arrows) and malaria pigment deposition (red arrowhead), and increased number of fibroblasts (double black arrows). Treatment with BM-MSCs reduced thickening of the alveolar–capillary barrier and decreased the number of myofibroblasts within interstitial tissue (double black arrow) and collagen deposition (double black arrows). b A semiquantitative, severity-based score was used to measure malaria pigment deposition, inflammation, fibrosis, and histoarchitectural damage in lungs of mice infected with P. berghei or mock-infected with saline and, 24 hours after infection, treated with BM-MSCs. Values are expressed as the median (interquartile range) of six animals in each group. *Significantly different from uninfected group (p <0.05). +Significantly different from P. berghei-infected group (p <0.05). BM-MSC bone marrow-derived mesenchymal stromal cell, Sal saline

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