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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Influence of erythropoietin on microvesicles derived from mesenchymal stem cells protecting renal function of chronic kidney disease

Fig. 3

Representative micrographs from each experimental group. a-b The control group presented polygonal or oval cells, arranged regularly, and showed the characteristics of cobblestone morphology in epithelial cells. c-d When TGF-β1 (6 ng/ml) was added to these groups to co-culture for 48 or 72 h, the cells lost connection, and the cobblestone morphology was replaced by hypertrophy and long spindle fibroblast-like morphology. Floating cells were increased, and fibrosis injury was more pronounced at 72 h. e-h MVs/EPO-MVs could partly suppress the HK2 cell morphological changes induced by TGF-β1. Most cells had normal morphology, the degree of fibrosis and its scope were appropriately reduced; in addition, the G-H groups had less fibrosis than the E-F groups. EPO erythropoietin HK2 human kidney 2 MVs microvesicles TGF-β1 transforming growth factor-β1

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