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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Influence of erythropoietin on microvesicles derived from mesenchymal stem cells protecting renal function of chronic kidney disease

Fig. 8

Changes in miRNA profiles of microvesicles (MVs) and EPO treated microvesicles (EPO-MVs). a Expression of miRNA in MVs and EPO-MVs, and mapping of hierarchical clustering of miRNA and heat map display of miRNA profiles. Columns represent individual samples, and each row represents individual assayed miRNA. Green represents down-regulation of miRNAs, and red represents up-regulation of miRNAs. b Fold regulation of significant miRNA in MVs versus EPO-MVs. Up-regulated miRNAs are denoted in red, downregulated miRNAs are green. c The relative miRNA change in MVs and EPO-MVs. The miR-299a-3p, miR-302b-5p, miR-499 and miR-200c-3p were all up-regulated in EPO-MVs; the up-regulation of miR-499 and miR-200c-3p was significant (p < 0.001, n = 3). d The bar plot shows the top ten enrichment score value of the significant enrichment pathway of the predicted possible target genes of miR-299a-3p, miR-302b-5p, miR-499 and miR-200c-3p. e The plot shows top ten biologic functions from the predicted possible target genes of miR-299a-3p, miR-302b-5p, miR-499 and miR-200c-3p, P-value cutoff (p < 0.05). EPO erythropoietin miRNA microRNA

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