Fig. 6

Osteopontin (OPN) promoted neurogenesis after stroke in vivo. a After single i.c.v. injection of 500 μg OPN in adult, unlesioned rats, OPN failed to significantly increase the area covered by doublecortin (DCX)-positive young neuroblasts in the SVZ. b In adults rats that underwent photothrombosis, a single i.c.v. injection of 500 μg OPN significantly increased the area covered by DCX-positive neuroblasts in the SVZ (values are displayed as means ± SEM, **p < 0.01). c Representative, DCX-stained images from the SVZ of rats subjected to cerebral ischemia, treated with either placebo (left) or OPN (right). OPN treatment led to an increase of neuroblasts in the SVZ (scale bar represents 100 μm)