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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection

Fig. 3

Transdifferentiation of transplanted mesenchymal stem cell (MSC)-derived neural-like cells in the injury/graft site of spinal cord. a Some of the grafted MSCs transdifferentiated into myelin-forming cells (white arrowheads, adenomatous polyposis coli (APC)-positive and myelin basic protein (MBP)-positive) in the NT-3-MSC (MN) + TrkC-MSCs (MT) group, but not in the MSCs group, at 8 weeks after transplantation. b Pie charts show the percentage of APC-positive and MBP-positive cells from grafted MSC-derived neural-like cells. c Grafted MSC-derived neural-like cells lost their affinity for the neuron markers (Tju-1-negative and microtubule-associated protein 2 (Map2)-negative) at 8 weeks after transplantation. At 3 days, the grafted MSC-derived neural-like cells were intensely immunostained with neuron markers (white arrowheads, Tju-1-positive and Map2-positive) and some of them began to express myelin-forming cell maker (white arrowhead, APC-positive). Scale bars = 25 μm. Tju-1, β-tubulin III

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