Skip to main content
Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Donor mesenchymal stem cell-derived neural-like cells transdifferentiate into myelin-forming cells and promote axon regeneration in rat spinal cord transection

Fig. 7

Outcomes of electrophysiology, myelin basic protein (MBP) protein level, and behavior at 8 weeks after cell transplantation. a Motor evoked potentials (MEPs) were obtained by electrophysiological analysis in the normal, gelatin sponge (GS), mesenchymal stem cells (MSCs), and NT-3-MSCs (MN) + TrkC-MSCs (MT) groups. b, c Bar charts of MEP latency and amplitude showed that shorter latency and higher amplitude of MEPs were exhibited in the MN + MT group compared with the GS (# P < 0.05) and MSCs (& P < 0.05) groups. d MBP expression in the GS, MSCs, and MN + MT groups was detected by Western blotting (WB). e Bar chart showed that the level of MBP expression was higher in the MN + MT group compared with the GS and MSCs groups (*P < 0.05, # P < 0.05). f Comparison of Basso, Beattie, and Bresnahan (BBB) score (mean ± standard deviation) of the handlimb locomotor function in spinal cord transected rats of the GS, MSCs, and MN + MT groups. In the MN + MT group, BBB score was higher than in the GS and MSCs groups (*P < 0.05, # P < 0.05). One-way analysis of variance with least significant difference test statistics was performed to compare the BBB score. g Three representative images of the handlimbs (red arrows) of the GS, MSCs, and MN + MT groups of rats which were climbing the inclined grids

Back to article page