Fig. 2
From: Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
Pharmacological effect of Wnt and Notch impairs wound healing. Full-thickness dermal wounds were induced in control rats, lithium chloride (LiCl)-treated rats, Dickkopf-1 (DKK1)-treated rats, recombinant human nuclear factor-kappa-B (rhNF-κB)-treated rats, and N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-treated rats. a Images of a representative mouse from each group taken on post-injury days 0, 7, 14, 21, and 30 are shown. b Wound areas are shown for control wounds, LiCl-treated wounds, and DKK1-treated wounds. The computation was that the indicated area was divided by the initial area. Results represent mean ± standard error of the mean (SEM) (n = 10 for each group). c Wound areas are shown for control wounds, rhNF-κB-treated wounds, and DAPT-treated wounds. The computation was that the indicated area was divided by the initial area. Results represent mean ± SEM (n = 10 for each group). *P < 0.01 compared with the control value