Fig. 3
From: Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
Histological features of wound healing in rats with decreased or increased Wnt and Notch activity. Images of skin tissue sections stained with hematoxylin and eosin (a) and Masson (b) showing histological changes during the wound-healing process in control, lithium chloride (LiCl)-treated, Dickkopf-1 (DKK1)-treated, recombinant human nuclear factor-kappa-B (rhNF-κB)-treated, and N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-treated rats at post-injury days 7, 14, and 30. Compared with control rats, LiCl-treated and rhNF-κB-treated rats exhibited a significant epidermal thickening, an orderly collagen, and regeneration of the skin appendages with enhanced wound healing. DKK1-treated and DAPT-treated rats exhibited delayed and poor-quality wound healing in comparison with control rats. Original magnification, 100×. Arrow pointed to neoformative epidermis layer