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Table 4 Biochemical changes in the studied groups

From: The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency

 

Pre treatment

2 weeks

1 month

2 months

3 months

6 months

9 months

12 months

Albumin

 Control

2.80 ± 0.15

2.80 ± 0.14

2.75 ± 0.19

2.73 ± 0.18

2.71 ± 0.21

2.68 ± 0.22

2.66 ± 0.22

2.64 ± 0.19

 Single infusion

2.58 ± 0.15

2.70 ± 0.22

2.79 ± 0.22

2.90 ± 0.24*

2.96 ± 0.35*

2.98 ± 0.33*

2.95 ± 0.33*

2.88 ± 0.30*

 Double infusion

2.84 ± 0.17

2.95 ± 0.13#

3.04 ± 0.14#

3.16 ± 0.14#*

3.28 ± 0.17#*

3.36 ± 0.20#*

3.39 ± 0.20#*

3.39 ± 0.21#*

s-Bilirubin

 Control

3.19 ± 0.89

3.23 ± 0.87

3.31 ± 0.92

3.32 ± 0.92

3.33 ± 0.92

3.36 ± 0.91

3.30 ± 0.88

3.24 ± 0.78

 Single infusion

3.59 ± 0.79

3.43 ± 0.77

3.39 ± 0.76

3.29 ± 0.83

3.18 ± 0.88

3.10 ± 0.93*

3.16 ± 0.81

3.18 ± 0.84#

 Double infusion

3.16 ± 0.99

3.07 ± 0.95

3.03 ± 0.96

2.96 ± 0.94

2.86 ± 0.98*

2.76 ± 0.98#*

2.77 ± 1.00#*

2.75 ± 0.98#*

INR

 Control

1.67 ± 0.16

1.62 ± 0.19

1.61 ± 0.21

1.67 ± 0.19

1.73 ± 0.19

1.73 ± 0.21

1.74 ± 0.20

1.72 ± 0.20

 Single infusion

1.76 ± 0.22

1.60 ± 0.32

1.54 ± 0.33

1.46 ± 0.34*

1.42 ± 0.36*

1.44 ± 0.34*

1.46 ± 0.29*

1.49 ± 0.28*

 Double infusion

1.68 ± 0.17

1.60 ± 0.20

1.57 ± 0.22

1.53 ± 0.22

1.49 ± 0.16*

1.44 ± 0.17*

1.43 ± 0.18*

1.41 ± 0.15*

Serum creatinine

 Control

1.06 ± 0.15

 

0.95 ± 0.10

0.94 ± 0.06

0.95 ± 0.09

0.96 ± 0.14

0.95 ± 0.11

0.93 ± 0.99

 Single infusion

0.92 ± 0.13

 

0.90 ± 0.15

0.92 ± 0.17

0.88 ± 0.16

0.89 ± 0.16

0.91 ± 0.12

0.89 ± 0.11

 Repeated infusion

1.04 ± 0.16

 

0.93 ± 0.10

0.91 ± 0.11

0.91 ± 0.09

0.90 ± 0.13

0.91 ± 0.22

0.92 ± 0.13

  1. Data presented as mean ± standard deviation
  2. *P <0.05 between single infusion or repeated infusion groups and the control group
  3. # P <0.05 between the single infusion and repeated infusion groups