Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis

Fig. 6

Model representing the main cellular events triggered by lentiviral-driven PG nuclear accumulation and their contribution to the premature aging. PG accumulation leads to modulation of mTOR and WnT pathways, alteration in the protein synthesis machinery and mitochondrial dysfunction and reactive oxygen species (ROS) overproduction, ultimately contributing to the premature aging phenotype

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512