Fig. 4
From: White matter injury restoration after stem cell administration in subcortical ischemic stroke
ADMSC administration led to a cell death reduction and improved brain proliferation activity. a Quantitative analysis of cell death by TUNEL technique showed a significant reduction in TUNEL-positive cells after ADMSC therapy compared to the control group (p < 0.05). b At 28 days, Ki-67 staining shows a significant increase in the number of proliferating cells in ADMSC-treated animals compared to the control group (p < 0.05). c At 28 days after treatment, Ki-67 co-labeling with NeuN, GFAP, and Olig-2 showed different cell type proliferation including oligodendrocytes. Data are shown as mean ± SEM; scale bars = 20 μm; n = 6 animals, 10 sections each per group. ADMSC adipose-derived mesenchymal stem cells, DAPI 4′,6-diamino-2-phenylindole, GFAP glial fibrillary acid protein, NeuN neuronal nuclei, Olig-2 oligodendrocite transcription factor 2