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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human-induced pluripotent stem cells generated from intervertebral disc cells improve neurologic functions in spinal cord injury

Fig. 3

The differentiation of diPSCs into derivatives of the three germ layers. a diPSCs (p15) were spontaneously differentiated in vitro, and the expression of representative markers of ectoderm (Nestin and beta-III tubulin), mesoderm (SMA and PECAM-1), and endoderm (AFP and FoxA2) was examined. b The derivatives of the three germ layers were detected in teratomas approximately 9–10 weeks after administration of diPSCs (2×106 cells) into nonobese diabetic/severe combined immunodeficiency mice. AFP alpha-fetoprotein, diPSC disc cell-derived induced pluripotent stem cell, FoxA2 forkhead box A2, PECAM-1 platelet endothelial cell adhesion molecule-1, SMA smooth muscle actin

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