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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: CDH1 and IL1-beta expression dictates FAK and MAPKK-dependent cross-talk between cancer cells and human mesenchymal stem cells

Fig. 8

Increased proliferation of MCF7 when co-cultured with hMSCs. MCF7 cells were co-cultured with hMSCs, and on day 7 cells were fixed and stained with the proliferation markers a Ki67 or b PCNA. Control staining is shown on each left panel. Arrowhead indicates cells with high Ki67 or PCAN staining. c Schema depicting possible interaction between hMSCs and tumor cells. Tumor cells with high CDH1 and low IL-1β will promote niche formation which might inhibit or promote tumor growth. Tumors with low CDH1 and high IL-1β will lead to rapid decline in hMSC numbers, and vice versa the number of tumor cells will decline as well and the hMSC niche will not form. Selective pressure exerted by MSCs could lead to regression of primary tumors and the acquisition of metastatic phenotype by tumor cells. GFP green fluorescent protein, IL interleukin, MSC mesenchymal (stromal) stem cell

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