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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Periostin enhances adipose-derived stem cell adhesion, migration, and therapeutic efficiency in Apo E deficient mice with hind limb ischemia

Fig. 4

Effects of periostin on the apoptosis of ADSCs under hypoxia. Apoptosis of GFP-ADSCs transfected with or without periostin under hypoxia a or normoxia b was analyzed using flow cytometry analysis. The apoptosis rates c indicated that overexpression of periostin effectively enhanced the viability of ADSC. Western blotting analysis revealed that the levels of anti-apoptotic Bcl-2 increased and pro-apoptotic Bax decreased d, and RT-PCR e showed that the ratio of Bcl-2/Bax was significantly higher in P-ADSCs than in ADSCs in normoxic and hypoxic treatments. *P <0.05. ADSC adipose-derived stem cell, GFP green fluorescent protein, P-ADSC periostin-transfected ADSC

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Stem Cell Research & Therapy

ISSN: 1757-6512