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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression

Fig. 2

Reduced MSC-mediated T-cell suppression capacity in patients with atherosclerosis and type 2 diabetes. a MSCs from patients with atherosclerosis (ATH; n = 18; *p = 0.02) have a decreased capacity to suppress CD4+ T-cell proliferation at 1:8 MSC:CD4+ T cell ratio compared to age-matched controls without atherosclerosis (non-ATH, n = 9). b MSCs from patients with ATH (n = 12) and type 2 diabetes mellitus (T2DM) (n = 12) have impaired suppressive capacity compared to age-matched ATH controls (*p = 0.04). c MSC function is compromised in age-matched patients with chronic inflammatory diseases (non-ATH < ATH < ATH+T2DM; n = 7 per group; *p = 0.02, **p = 0.002)

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