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Table 1 Effect of let-7b-MSCs on cardiac function in ischemia/reperfusion animal model

From: let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3

 

Control

I/R

I/R + MSCs

I/R + let-7b-MSCs

EF (%)

69.68 ± 1.48

40.96 ± 2.42

53.4 ± 0.92*

65.29 ± 1.15**

ESV (μl)

62.67 ± 1.82

120.96 ± 1.95

87.85 ± 1.95*

74.52 ± 1.25**

EDV (μl)

124.43 ± 1.06

189.49 ± 1.95

149.48 ± 2.17*

135.93 ± 2.00*

CO (μl/minute)

37 675.1 ± 2584.66

16 335.9 ± 925.71

24 154.9 ± 589.04

28 580 ± 500.51*

SW (mmHg* μl)

12 710 ± 896

6335 ± 475

10 245 ± 350*

12 526 ± 442*

SV (μl)

156.91 ± 10.57

76.9 ± 5.79

110.14 ± 7.09*

112.68 ± 1.69*

  1. All values expressed as mean ± standard error of the mean
  2. *p <0.05 vs. I/R group
  3. **p <0.001 vs. I/R group
  4. CO cardiac output, EDV end-diastolic volume, EF ejection fraction, ESV end-systolic volume, I/R ischemia/reperfusion, MSC mesenchymal stem cell, SV stroke volume, SW 1:13 stroke work