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Table 1 Effect of let-7b-MSCs on cardiac function in ischemia/reperfusion animal model

From: let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia/reperfusion injured heart 7by targeting caspase-3

  Control I/R I/R + MSCs I/R + let-7b-MSCs
EF (%) 69.68 ± 1.48 40.96 ± 2.42 53.4 ± 0.92* 65.29 ± 1.15**
ESV (μl) 62.67 ± 1.82 120.96 ± 1.95 87.85 ± 1.95* 74.52 ± 1.25**
EDV (μl) 124.43 ± 1.06 189.49 ± 1.95 149.48 ± 2.17* 135.93 ± 2.00*
CO (μl/minute) 37 675.1 ± 2584.66 16 335.9 ± 925.71 24 154.9 ± 589.04 28 580 ± 500.51*
SW (mmHg* μl) 12 710 ± 896 6335 ± 475 10 245 ± 350* 12 526 ± 442*
SV (μl) 156.91 ± 10.57 76.9 ± 5.79 110.14 ± 7.09* 112.68 ± 1.69*
  1. All values expressed as mean ± standard error of the mean
  2. *p <0.05 vs. I/R group
  3. **p <0.001 vs. I/R group
  4. CO cardiac output, EDV end-diastolic volume, EF ejection fraction, ESV end-systolic volume, I/R ischemia/reperfusion, MSC mesenchymal stem cell, SV stroke volume, SW 1:13 stroke work