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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

Fig. 3

Analysis of the growth of human hematopoietic colonies from bone marrow cells isolated from humanized mice 24 h after induction of experimental sepsis. Twenty-four hours after induction of experimental sepsis, bone marrow cells (5 × 105) from hu-NSG were seeded on methylocellulose medium supplemented with human growth factors. After 20 days of culture, the colonies formed by human progenitor cells were counted. a Results from the model of endotoxemia. b Results from the CLP-induced sepsis model. n = 6, *P < 0.05, **P < 0.01. BMC bone marrow cell, CLP cecal ligation and puncture surgery, hu-NSG humanized NOD.Cg-Prkdc/scidIL2rγ

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Stem Cell Research & Therapy

ISSN: 1757-6512