Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

Fig. 4

Modulation of the expression of TLR4 and CXCR4 receptors on human HSCs. Changes of TLR4 (a, c) and CXCR4 (e) expression on CD34+ CD38− cells 24 h after single LPS injection. Impact of CLP model on the modulation of TLR4 receptor expression (b, d) and CXCR4 expression (f). Representative histograms of TLR4 (g) and CXCR4 (h) expression on CD34+ CD38− HSCs from control and CLP mice are presented. n = 6, *P < 0.05, **P < 0.01. CLP cecum ligation and puncture, GMF geometric mean fluorescence, HSC hematopoietic stem cell, LPS lipopolysaccharide, TLR Toll-like receptor

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512