Fig. 3

Paclitaxel (PTX) uptake/release by human amniotic mesenchymal stromal cells (hAMSCs). a Release of PTX over time evaluated in four out of seven donors. Bars represent the amount of PTX (expressed as picograms/cell) released at each time point, and the curve expresses the total amount of PTX released over time. b Proliferation curves of CFPAC-1 in the presence of serial dilutions of PTX (white circles) or conditioned media from PTX-primed hAMSCs (hAMSCsPTX-CM) (black circles). Each point represents the mean value ± SD. The curve of hAMSCsPTX-CM represents mean values obtained from seven donors. The half maximal inhibitory concentration (IC ₅₀ ) and the volume of CM able to inhibit tumor growth by 50 % (V ₅₀ ) are shown. PEC paclitaxel equivalent concentration