From: Endpoints in stem cell trials in ischemic heart failure
Symptoms | Functional domain | LV function remodeling | Quality of life |
---|---|---|---|
A change in NYHA class | a) Increase of 50 m in 6-min walk test b) Increase of 10 % in VO2max | a) Increase of 5 % in absolute LVEF or; b) Decrease of 20 mL or 20 % (whichever is greater) in LVESV c) Decrease in NTproBNP by 35 % or 300 pg/ml, whichever is greater | a) Improvement in MLHF-Q ≥10 b) Improvement in KCCQ ≥20 |