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Table 1 Markers and potential functions of native BM-MSCs

From: Where is the common ground between bone marrow mesenchymal stem/stromal cells from different donors and species?

In-vivo MSC marker

Potential function on MSCs

Host/model

References

CD271

Osteogenesis

Human, murine cell line

[96]

 

Interactions with other BM cells

Human

[51, 97]

MSCA-1/Stro-3/non-specific alkaline phosphatase

Osteogenesis/mineralization

Human

[34, 98]

Stro-1

Migration/homing

Human

[99]

CD146

Related to MSC topography, interaction with other BM cells

Human

[24, 50, 54, 100]

Leptin R (CD295)

Controlling bone–fat balance

Mouse

[60]

 

Age-related

Human

[64]

PDGFRα (CD140a)

Related to immaturity

Mouse/human

[48]/[65]

 

Support HSCs

Mouse/human

[30]

 

Early adipogenic commitment

Mouse/human

[101]

PDGFRβ (CD140b)

Proliferation

Human

[61]

CD49a

Receptor for collagen and laminin

Human

[39, 102, 103]

CD106

Migration

Human

[50, 51]

 

Interaction with other BM cells

 

[51]

CD51

Interaction with HSCs

Mouse/human

[30]

CD200

Immunoregulation

Human

[104]

CD90

Interactions with other BM cells

Human

[39]

  

Mouse

[51]

  1. BM bone marrow, HSC hematopoietic stem cell, MSC mesenchymal stem/stromal cell, MSCA-1 mesenchymal stem cell antigen-1, PDGFR platelet-derived growth factor receptor