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Table 2 Relative saturated very long chain fatty acid levels in cultured patient- and control-derived cells

From: Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities

 

C26:0LPC/C22:0 LPCa

%C26:0LPCa

Cell type

Mean control

Mean patient

FCb

P c

Mean control

Mean patient

FCb

P c

Fibroblastd

1.24

16.44

13.3

<3×10−4

0.82

10.33

12.6

<9×10−6

Fibroblaste

0.70

13.96

19.8

<7×10−3

0.23

3.36

14.3

0.01

iPSCf

6.61

1.31

−5.0

0.001

0.36

0.11

−3.4

0.07

NPCg

7.12

8.25

1.2

0.8

1.68

1.60

−1.1

0.9

  1. aGeometric means of the indicated ratios are provided. %C26:0LPC relative to the sum of all LPCs and Lyso-PAFs measured (see Methods). bFold-change (FC): ratio of patient to control data. cBased on two-tailed Student t-test of log-transformed data. dCultured in fibroblast growth media (three control, five patient samples); eCultured in iPSC growth media (three control, five patient samples). fInduced pluripotent stem cells (iPSCs): four control, 15 test samples; gNeural progenitor cells (NPCs): two control, seven patient samples