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Table 2 Relative saturated very long chain fatty acid levels in cultured patient- and control-derived cells

From: Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities

  C26:0LPC/C22:0 LPCa %C26:0LPCa
Cell type Mean control Mean patient FCb P c Mean control Mean patient FCb P c
Fibroblastd 1.24 16.44 13.3 <3×10−4 0.82 10.33 12.6 <9×10−6
Fibroblaste 0.70 13.96 19.8 <7×10−3 0.23 3.36 14.3 0.01
iPSCf 6.61 1.31 −5.0 0.001 0.36 0.11 −3.4 0.07
NPCg 7.12 8.25 1.2 0.8 1.68 1.60 −1.1 0.9
  1. aGeometric means of the indicated ratios are provided. %C26:0LPC relative to the sum of all LPCs and Lyso-PAFs measured (see Methods). bFold-change (FC): ratio of patient to control data. cBased on two-tailed Student t-test of log-transformed data. dCultured in fibroblast growth media (three control, five patient samples); eCultured in iPSC growth media (three control, five patient samples). fInduced pluripotent stem cells (iPSCs): four control, 15 test samples; gNeural progenitor cells (NPCs): two control, seven patient samples