| C26:0LPC/C22:0 LPCa
| %C26:0LPCa
|
---|
Cell type | Mean control | Mean patient | FCb
|
P
c
| Mean control | Mean patient | FCb
|
P
c
|
---|
Fibroblastd
| 1.24 | 16.44 | 13.3 | <3×10−4
| 0.82 | 10.33 | 12.6 | <9×10−6
|
Fibroblaste
| 0.70 | 13.96 | 19.8 | <7×10−3
| 0.23 | 3.36 | 14.3 | 0.01 |
iPSCf
| 6.61 | 1.31 | −5.0 | 0.001 | 0.36 | 0.11 | −3.4 | 0.07 |
NPCg
| 7.12 | 8.25 | 1.2 | 0.8 | 1.68 | 1.60 | −1.1 | 0.9 |
-
aGeometric means of the indicated ratios are provided. %C26:0LPC relative to the sum of all LPCs and Lyso-PAFs measured (see Methods). bFold-change (FC): ratio of patient to control data. cBased on two-tailed Student t-test of log-transformed data. dCultured in fibroblast growth media (three control, five patient samples); eCultured in iPSC growth media (three control, five patient samples). fInduced pluripotent stem cells (iPSCs): four control, 15 test samples; gNeural progenitor cells (NPCs): two control, seven patient samples