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Table 2 Distribution and phenotypic profile of CD13high CD105+ CD45 cells in normal versus reactive bone marrow samples

From: Ex vivo identification and characterization of a population of CD13high CD105+ CD45 mesenchymal stem cells in human bone marrow

  Normal BM
(n = 9)
Reactive BM
(n = 51)
Antigenic profile % positive cells MFI % positive cells MFI
% CD13high CD105+ CD45 cells 0.008 (0.0004–0.04) 0.03 (0.0007–0.6)*
CD10 91 % 7624 88 % 6916
(75–97 %) (2069–22,177) (62–97 %) (1883–14,821)
CD11b NA NA NA NA
CD13 100 % 162,716 100 % 114,760
(100–100 %) (58,223–260,438) (100–100 %) (45,582–182,771)
CD14 NA NA NA NA
CD19 NA NA NA NA
CD34 NA NA NA NA
CD45 NA NA NA NA
CD73 100 % 7241 100 % 8149
(100–100 %) (3268–23,090) (100–100 %) (4462–16,288)
CD90 100 % 64,102 100 % 17,729*
(100–100 %) (12,081–260,738) (100–100 %) (1870–108,409)
CD105 100 % 2598 100 % 2463
(100–100 %) (700–3420) (100–100 %) (1299–4620)
CD117 NA NA NA NA
CD146 100 % 733 100 % 502
(100–100 %) (292–2992) (100–100 %) (267–3054)
HLA-DR 98 % 4038 87 % 2589
(78–100 %) (390–11,726) (50–100 %) (407–15,823)
  1. Results expressed as median (range) percentage of positive cells and MFI calculated after subtracting baseline autofluorescence levels
  2. *P < 0.05 versus normal BM
  3. BM bone marrow, MFI median fluorescence intensity (expressed as arbitrary fluorescence units scaled from 0 to 262,000), NA not appropriate (as these markers were absent on CD13high CD105+ CD45 cells)