Fig. 3

BCSCs exhibit decreased expression of several metabolic genes relative to SCs. a, b Representative FACS plots of subpopulations isolated from a benign or b malignant breast tissue. c Average percentage of total CD45⁻, CD31⁻ (lin^–) stem, and progenitor subpopulations isolated from benign (gray, n = 15) or malignant (green, n = 11) breast tissue. Error bars represent standard deviation of the mean. d–g Gene expression was determined for subpopulations of BCSCs (n = 13) relative to SC counterparts (n = 9). HIF-1α and nonglycolytic HIF-1α-inducible gene targets (red), HIF-1α-dependent glycolytic gene targets (purple), and HIF-1α-independent glycolytic gene targets (blue) are color coded. Error bars represent the 95 % confidence interval