Fig. 2
SHED ameliorate the hepatic dysfunction in recipient livers of CCl4-treated mice. a Serum assays for the hepatic function. b–f Liver fibrosis assays. b Representative images of livers. Masson Trichrome staining. Arrowheads, fibrous deposition. c Fibrotic area. d Fibrotic score. e Hydroxyproline assay in recipient livers. f Real-time RT-PCR analysis of mouse type I collagen (mCola1) mRNA in recipient livers. a, c–f n = 5 for all groups. Control, olive oil-injected group; CCl4, CCl4-treated group; CCl4 + SHED, SHED-transplanted CCl4-treated group. *P <0.05 and ***P <0.005. ns no significance. Graph bars show the mean ± SD. ALT alanine aminotransferase, ALP alkaline phosphatase, AST aspartate aminotransferase, CCl 4 carbon tetrachloride, SHED stem cells from human exfoliated deciduous teeth