Fig. 3From: In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in miceSHED transplantation suppresses the activation of hepatic stellate cells in livers of CCl4-treated mice. a–c Expression of alpha smooth muscle actin (αSMA). a Immunohistochemical staining with anti-αSMA antibody in recipient livers. b αSMA-positive area. c Real-time RT-PCR analysis of mouse αSMA (mαSMA) mRNA. d, e Real-time RT-PCR analysis. d Expression of mouse MMP9 and MMP2 (mMMP9, mMMP2) and mouse TIMP1 and TIMP2 (mTIMP1, mTIMP2) mRNA in recipient livers. e Expression of mouse interleukin-6 (mIL-6), mouse transforming growth factor β1 (mTGFβ1), and mouse tumor necrosis factor alpha(mTNFα) mRNA in recipient livers. b–e n = 5 for all groups. *P <0.05, **P <0.01, and ***P <0.005. ns no significance. Graph bars show the mean ± SD. Control, olive oil-injected group; CCl4, CCl4-treated group; CCl4 + SHED: SHED-transplanted CCl4-treated group. CCl 4 carbon tetrachloride, MMP matrix metalloproteinase, SHED stem cells from human exfoliated deciduous teeth, TIMP tissue inhibitor of matrix metalloproteinaseBack to article page