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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Umbilical cord blood-derived CD11c+ dendritic cells could serve as an alternative allogeneic source of dendritic cells for cancer immunotherapy

Fig. 2

Functional characterization of dendritic cells (DCs). a FACS histogram overlays of dextran-fluorescein isothiocyanate (FITC) uptake profile of a representative experiment from umbilical cord blood DCs (UCB-DCs) and peripheral blood DCs (PBL-DCs) with mean fluorescence intensity (MFI) values in brackets, and b data from three experiments for percentage antigen uptake. c Cumulative MFI values from three samples. d Chemotaxis of DCs towards CCL-19. Low spontaneous migration was observed in the wells, without CCL-19, whereas both UCB-DCs and PBL-DCs efficiently migrated towards CCL-19 gradient. e Mixed lymphocyte reaction (MLR) from three independent experiments reveals that DCs generated from both sources exhibited similar MLR at a different effector-to-target ratio. The data shown are mean ± SD, n = 3 (**p <0.01). CPMA count per minute for beta

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Stem Cell Research & Therapy

ISSN: 1757-6512