Fig. 2
From: Targeting stem cell niche can protect hematopoietic stem cells from chemotherapy and G-CSF treatment
Chemotherapy destroys bone marrow niche osteoblasts in autologous transplantation patients. a Serum osteocalcin concentrations decrease after multiple rounds of cytotoxic drug treatment in human. Serum samples were collected from 10 patients and their serum osteocalcin levels were measured by enzyme-linked immunosorbent assay (ELISA). b, c Representative photomicrographs of human endosteal osteoblasts after immunohistochemical staining. Osteocalcin-positive mature osteoblasts (red arrows) before treatment (b) were considerably reduced at steady state (c) of G-CSF treatment