Fig. 5

adCD-MSCs/hCBPL decrease systemic inflammatory response in DSS-induced colitis mouse model. Plasma was obtained from mice blood, collected from the caudal vein. a–f Cytokine levels (IL-1β, IL-17, TNFα, IL-6, IL-10, IFNγ) were measured using Bioplex assay at the start of the experiment (day +0), at the end of DSS treatment (day+9), after the administration of PBS (black column), hCBPL alone (white column), adCD-MSCs (light gray column), or adCD-MSCs/hCBPL (dark gray column) (day +11), at day +18, and at the end of the experiment (day +22). Data expressed as mean ± SEM. n = 4–8 mice per group. *p <0.05 with respect to DSS+PBS group; #p <0.05 in the comparison between the MSC groups. adCD-MSC mesenchymal stromal cell isolated from adipose tissue of Crohn’s disease patients, DSS dextran sulfate sodium, hCBPL human umbilical cord blood-derived platelet lysate, IFN-γ interferon gamma, IL interleukin, PBS phosphate saline buffer, TNFα tumor necrosis factor alpha