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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: 1H-pyrrole-2,5-dione-based small molecule-induced generation of mesenchymal stem cell-derived functional endothelial cells that facilitate rapid endothelialization after vascular injury

Fig. 2

Transplantation of iMDFECs after vascular injury significantly inhibited neointima formation and achieved rapid endothelialization of denuded vessels in vivo. a Tracking transplanted iMDFECs by using Y chromosome staining (fluorescence in situ hybridization). Left scale bar = 12.5 μm. Right scale bar = 50 μm. b Representative images of an Evans Blue-stained carotid artery showing transmural coverage (upper panels) and a cross-section of a hematoxylin-and-eosin-stained carotid artery to show neointima formation (bottom panels). More blue indicates increased permeability. Scale bar = 200 μm. c Time-dependent changes in transluminal coverage were plotted against neointima thickness (n = 3). See Additional file 9: Figure S8 for statistical significance. DAPI 4ʹ,6-diamidino-2-phenylindole, iMDFEC induced mesenchymal stem cell-derived functional endothelial cell, MSC mesenchymal stem cell, SMC smooth muscle cell

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