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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries

Fig. 6

L-PRP induces greater catabolic responses than P-PRP. Gene expression analysis of the catabolic markers, MMP-1 and MMP-13, by quantitative reverse transcription-polymerase chain reaction (a). Unlike P-PRP, L-PRP significantly induced the expression of both catabolic genes. The control group was used as the reference. Gene expression levels were normalized to the expression of GAPDH (glyceraldehyde 3-phosphate dehydrogenase). Data are represented as mean ± SD of three independent values. MMP production was also measured by using enzyme-linked immunosorbent assay (b). The production was normalized to respective cell number in each group. Asterisks represent significant differences when compared with the respective control, and the pound symbols indicate significant differences between L-PRP and P-PRP (P < 0.05). Note that the data for each group were calculated from three independent values. Data are expressed as the mean ± SD. A t test was used for statistical analysis. L-PRP leukocyte-platelet-rich plasma, MMP matrix metalloproteinase, P-PRP pure-platelet-rich plasma, SD standard deviation

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