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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer

Fig. 4

Vertical stacked bars from QPCR profiling showing the regulation of FIR-amplified stem cell-related transcription with HT-EA treatment in ALDH+CD44+CD24+ PC-CSCs derived from xenografts established using MiaPaCa-2, Panc-1, Panc-3.27, and BXPC-3. Inhibitory potential of HT-EA was compared for the 43 genes that showed cell line-independent increase after fractionated radiation across all four PC-CSC clones investigated. Cell line-independent effect of HT-EA for any given gene is indicated with “‡” for four, with “†” for three, and with “*” for two PC-CSC clones; “∆” for cell line-dependent effect. In the stacked bar, PT-EA + FIR bars are overlaid on top of the FIR bars and the y axis is restricted to a maximum of 20-fold for better presentation of comparative display. Overall, HT-EA treatment exerted cell line-independent inhibition of 14 of the 43 FIR-induced genes (ALDH1A1, ALPI, APC, AXIN1, BGLAP, CD4, CDC42, CTNNA1, GJB1, HDAC2, HRAS, JAG1, SHH, TBX2). CSC cancer stem cell, FIR fractionated irradiation, HT-EA ethyl acetate polyphenol fraction of Hormophysa triquerta, PC pancreatic cancer

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