Fig. 4
From: Mesenchymal stem cells stabilize the blood–brain barrier through regulation of astrocytes
MSC treatment reduces LPS-induced neutrophil infiltration and loss of dopaminergic cells in the midbrain. There was a marked increase in MPO-positive cells in LPS-induced animals; however, MSC treatment following LPS administration notably decreased the number of these cells a (n = 5). **p <0.001. Scale bar: 100 μm. Consequently, MSC treatment inhibited LPS-induced loss of TH-positive cells in the midbrain b (n = 5). *p <0.05. Behavioral analysis showed that the number of rotations after apomorphine injection was significantly increased in animals receiving LPS compared with controls, whereas MSC administration led to a significant reduction of rotation behavior in LPS-treated animals c (n = 5). **p <0.001. Scale bar: 100 μm. LPS, lipopolysaccharide, MSC mesenchymal stem cell, MPO myeloperoxidase, TH tyrosine hydroxylase