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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration

Fig. 7

A cytokine antibody array to examine cytokine secretion by WJ-MSCs. a A cytokine antibody array was used to compare cytokine secretion between MSC-lowTR and MSC-highTR. TGFβ ligands (TGFβ1, TGFβ2, and TGFβ3) are secreted by both MSC-lowTR and MSC-highTR with no difference. Expression of GDF-15 and MMP-1 is much higher in MSC-highTR than in MSC-lowTR, whereas expression of CCL-5 is much higher in MSC-lowTR than in MSC-highTR. b Quantification of the amounts of cytokines secreted by MSC-lowTR and MSC-highTR, as determined by ImageJ analysis (n = 3). **p <0.01. ALK5 activin-like kinase receptor 5, CCL-5 chemokine (C-C motif) ligand 5, GDF-15 growth differentiation factor-15, MMP-1 matrix metalloproteinase-1, MSC-highTR Wharton’s Jelly-derived mesenchymal stem cells highly expressing TβRI/ALK5 and TβRII, MSC-lowTR Wharton’s Jelly-derived mesenchymal stem cells lowly expressing TβRI/ALK5 and TβRII, TβR transforming growth factor-beta receptor

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