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Table 1 Genes differentially upregulated in HBF clones + hBMSC-TERT+Bone versus LBF clones + hBMSC-TERT–Bone

From: Association between in vivo bone formation and ex vivo migratory capacity of human bone marrow stromal cells

Category PROBE_ID Gene symbol Gene name Fold change p value Gene function
Migration ILMN_1798360 CXCR7 Chemokine (C-X-C motif) receptor 7 30.34323 1.57 × 10–5 Receptor for CXCL12/SDF1
  ILMN_1689111 CXCL12 Chemokine (C-X-C motif) ligand 12 7.64381 6.57 × 10–5 Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis
  ILMN_2373791 ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 6.481839 1.58 × 10–13 Leukocyte-endothelial cell adhesion
  ILMN_1722713 FBLN1 Fibulin 1 5.060076 8.1 × 10–17 Plays a role in cell adhesion and migration
  ILMN_2082585 SNAI2 Snail homolog 2 4.84552 3.28 × 10–25 Involved in the generation and migration of neural crest cells
  ILMN_1811313 SLIT3 Slit homolog 3 4.378596 1.14 × 10–15 Acts as molecular guidance cue in cellular migration
  ILMN_1802646 EPHB6 EPH receptor B6 4.171862 0.00022 Modulates cell adhesion and migration
  ILMN_2086470 PDGFRA Platelet-derived growth factor receptor, alpha polypeptide 4.168592 0.009945 Receptor that binds both PDGFA and PDGFB
  ILMN_2339266 LAMA2 Laminin, alpha 2 3.959818 5.47 × 10–6 Mediates the attachment, migration, and organization of cells into tissues during embryonic development
  ILMN_2307903 VCAM1 Vascular cell adhesion molecule 1 3.080952 7.75 × 10–5 Plays a role in leukocyte endothelial cell adhesion
  ILMN_1757338 PLSCR4 Phospholipid scramblase 4 2.885336 0.008172 Mediates bidirectional transbilayer migration of phospholipids, plays a central role in the initiation of fibrin clot formation and activation of mast cells and in the recognition of apoptotic and injured cells
  ILMN_1761540 SEMA3F Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3 F 2.657031 8.68 × 10–8 Plays a role in cell motility and cell adhesion
  ILMN_1659306 SVIL Supervillin 2.569266 0.001237 May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration
  ILMN_1667893 TNS3 Tensin 3 2.446932 5.1 × 10–6 Involved in cell migration and bone development
  ILMN_1815057 PDGFRB Platelet-derived growth factor receptor 2.147921 5.33 × 10–10 Receptor that binds both PDGF-AA and PDGF-BB
Adhesion ILMN_2408683 PPAP2B Phosphatidic acid phosphatase type 2B 8.923443 4.45 × 10–11 May be involved in cell adhesion and in cell–cell interactions
  ILMN_1684554 COL16A1 Collagen, type XVI, alpha 1 3.998721 4.96 × 10–12 Involved in mediating cell attachment and induction of integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology
  ILMN_1801246 IFITM1 Interferon induced transmembrane protein 1 (9–27) 3.467308 1.36 × 10–14 Component of a complex involved in adhesion signals
  ILMN_2396444 CD14 CD14 molecule 3.169754 0.000265 Upregulates cell surface molecules, including adhesion molecules
  ILMN_2307903 VCAM1 Vascular cell adhesion molecule 1 3.080952 7.75 × 10–5 Plays a role in leukocyte endothelial cell adhesion
  ILMN_2229877 PCDH18 Protocadherin 18 2.939445 6.56 × 10–8 Potential calcium-dependent cell-adhesion protein
  ILMN_1761540 SEMA3F Sema domain, immunoglobulin domain (Ig), short basic domain, secreted 2.657031 8.68 × 10–8 May play a role in cell motility and cell adhesion
  ILMN_1812461 WISP2 WNT1 inducible signaling pathway protein 2 2.336378 0.001181 Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors
  ILMN_1769575 JAM3 Junctional adhesion molecule 3 2.195171 4.39 × 10–5 May participate in cell–cell adhesion
  ILMN_2223941 FBLN5 Fibulin 5 2.099419 0.000119 Promotes adhesion of endothelial cells through interaction of integrins
  ILMN_2115125 CTGF Connective tissue growth factor 2.037551 3 × 10–9 Mediates heparin-dependent and divalent cation-dependent cell adhesion
  ILMN_1707070 PCOLCE Procollagen C-endopeptidase enhancer 2.023961 1.28 × 10–5 Procollagen C-endopeptidase enhancer
Bone formation ILMN_1696391 LEPR Leptin receptor 9.88173 0.000244 Leptin receptor
  ILMN_1690945 CPZ Carboxypeptidase Z 6.636527 2.46 × 10–11 Modulates the Wnt signaling pathway
  ILMN_1800317 WNT5A Wingless-type MMTV integration site family, member 5A 4.39779 5.65 × 10–6 Can activate or inhibit canonical Wnt signaling
  ILMN_1709734 BMP4 Bone morphogenetic protein 4 3.425185 0.003465 Induces cartilage and bone formation
  ILMN_1758895 CTSK Cathepsin K (CTSK), mRNA. 2.655974 0.000136 Closely involved in osteoclastic bone resorption
  ILMN_1684755 KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.583283 0.001055 Involved in the proliferation of osteoblasts during bone formation and bone regeneration
  ILMN_1724480 AXIN2 Axin 2 2.432503 5.5 × 10–7 Downregulates beta-catenin
  ILMN_1770161 BST1 Bone marrow stromal cell antigen 1 2.417137 0.002254 Involved in osteoclastic bone resorption
  ILMN_1729368 FZD8 Frizzled homolog 8 2.013491 0.005335 Receptor for Wnt proteins
Cytoskeletal ILMN_1812031 PALM Paralemmin 9.661952 0.004851 Control of cell shape
  ILMN_1780334 KCNJ2 Potassium inwardly-rectifying channel, subfamily J, member 2 9.409812 1.23 × 10–21 Participates in establishing action potential waveform and excitability of neuronal and muscle tissues
  ILMN_1654319 HAPLN3 Hyaluronan and proteoglycan link protein 3 6.178261 3.95 × 10–27 May function in hyaluronic acid binding
  ILMN_1741695 COL12A1 Collagen, type XII, alpha 1 2.071144 0.008916  
  ILMN_1670899 FBN2 Fibrillin 2 2.065329 0.000762 Contains microfibrils that regulate the early process of elastic fiber assembly
  ILMN_1674620 SGCE Sarcoglycan, epsilon 2.034948 7.35 × 10–6 A subcomplex of the dystrophin–glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix
  ILMN_1780334 KCNJ2 Potassium inwardly-rectifying channel, subfamily J, member 2 9.409812 1.23 × 10–21 Participates in establishing action potential waveform and excitability of neuronal and muscle tissues
  1. HBF high bone forming, hBMSC human bone marrow-derived stromal cells, LBF low bone forming, PDGF platelet-derived growth factor
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Stem Cell Research & Therapy

ISSN: 1757-6512