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Table 1 Functional categories of common proteins identified in all normoxic ADSC secretomes

From: Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes

GO term

Counta

%

P value**

Proteins (Uniprot acc no.)

Examples

GO:0005578 ~ proteinaceous extracellular matrix

41

41.4

<0.001

P02751, P05997, P01033, P20908, P27797, Q99715, P02461, Q16610, P16035, P09486, P28300, P07942, P11047, P98160, P98095, P12110, P14543, P12111, Q9UBX5, P02452, P23142, P55268, Q16363, P35555, Q15582, P08123, O95967, P07585, P24821, P51884, P12109, P08254, P08253, Q08629, P21810, Q12805, Q15063, Q08380, Q14767, P13611, P03956

Collagens, collagen-maturation enzymes, collagen interacting proteins, elastin-associated molecules, matricellular proteins, laminins

GO:0005509 ~ calcium ion binding

35

35.4

<0.001

Q02818, P35442, P19022, P27797, P09871, Q92626, P12814, P09486, P11021, O43707, P07996, P98095, P00736, P14543, Q9UBX5, Q15293, P23142, Q12841, P80303, P15289, P35555, O95967, O94985, Q9BRK5, P06396, P13497, P08254, P08253, Q08629, P67936, Q12805, O43852, Q14767, P13611, P03956

calsyntenin 1; heat shock 70 kDa protein 5; reticulocalbin 1; stromal cell derived factor 4; calumenin; nucleobindin 1,2; calreticulin

GO:0007155 ~ cell adhesion

31

31.3

<0.001

Q16270, P35442, P02751, P20908, P19022, Q99715, P02461, P12814, P07942, P11047, P07996, P98160, P12110, P12111, P14543, Q9UBX5, P05067, P55268, Q16363, Q15582, P35579, O94985, P24821, Q8IUX7, P13497, P12109, Q08629, Q15063, Q08380, O14498, P13611

Lectin 3 binding protein; BMP1; AE binding protein 1;N-cadherin; IGFBP-7; TGFBIP

GO:0006928 ~ cell motion

14

14.1

<0.001

P02751, P20908, P19022, P60709, P05067, P35579, Q13822, P09493, P06753, Q08629, P67936, P11047, P07996, P13611

Extracellular lysophospholipase D; tropomyosins 1, 3, 4

GO:0008233 ~ peptidase activity

13

13.1

<0.001

P30101, O14773, P16870, P07858, P09871, P05067, Q8IUX7, P13497, P08254, P08253, P05121, P03956, P00736

MMP1, 2; carboxypeptidase E; cathepsin B; tripeptidyl peptidase I

GO:0004866 ~ endopeptidase inhibitor activity

12

12.1

<0.001

P16035, P36955, P01033, P12111, P05155, P05121, P11021, P50454, P05067, P07093, Q6YHK3, P01034

PEDF; TIMP1,2; PAI-1, 2; cystatin C

GO:0001568 ~ blood vessel development

11

11.1

<0.001

P20908, P19022, P08253, P02452, P28300, P21810, Q16363, P02461, P07996, P35579, P08123

N-cadherin; thrombospondin 1, 2; biglycan; lysyl oxidase

GO:0042060 ~ wound healing

10

10.1

<0.001

P02751, P09493, P20908, P05155, P06396, P05121, Q9UBX5, P28300, P02461, O95967

Fibulins 4, 5; collagen, type III; fibronectin 1

GO:0006955 ~ immune response

10

10.1

0.037

P61769, P05155, P26022, O75326, P10909, P09871, Q92626, P07996, Q13822, P00736

pentraxin 3; Sem7A; β2-microglobulin; clusterin

GO:0060348 ~ bone development

7

7.1

<0.001

P05997, P13497, P08253, P09486, P02452, P17936, P98160

Perlecan; osteonectin; BMP1; IGFBP 3

GO:0031175 ~ neuron projection development

6

6.1

0.027

P10909, P07942, P60709, P05067, P55268, P13611

Versican; amyloid beta (A4) precursor protein

GO:0060284 ~ regulation of cell development

5

5.1

0.046

P16035, P36955, P19022, P27797, P17936

N-cadherin; PEDF; TIMP2; IGFBP 3

GO:0031099 ~ regeneration

4

4

0.011

P06396, P05121, P55268, P13611

PAI-1, laminin S; gelsolin

GO:0007178 ~ transmembrane receptor protein serine/threonine kinase signaling pathway

4

4

0.030

Q12841, P02461, P08123, Q14767

CD109; DKK3; follistatin-like 1

GO:0016860 ~ intramolecular oxidoreductase activity

3

3

0.027

P30101, P07237, P41222

prolyl 4-hydroxylase; prostaglandin D2 synthase

  1. ADSC adipose-derived mesenchymal stromal cells, GO Gene Ontogeny, TGFBIP transforming growth factor, beta-induced, 68 kDa, IGFBP insulin-like growth factor binding protein
  2. aProteins annotated to different functional clusters partially overlap
  3. **p value according to kappa statistics (DAVID Bioinformatics Resources, https://david.ncifcrf.gov) [22, 47]