Table 3 Electrophysiological properties of Sim1-Puro selected cells

Capacitance (pF)

18.3 ± 1.3 (51)

24.2 ± 0.9 (68)^a

Input Resistance (GOhm)

1.64 ± 0.49 (51)

0.96 ± 0.17 (68)^a

V rest (mV)

−28.5 ± 2.1 (43)

−43.7 ± 1.2 (64)^a

% V rest less than −50 mV

5 %

28 %^a

Rheobase (pA)

10.6 ± 2.3 (14)

18.3 ± 2.7 (34)

1^st spike latency (msec)

214 ± 43 (14)

153 ± 19 (24)

1^st spike amplitude (mV)

84 ± 4.5 (14)

95 ± 3.5 (24)

absolute amplitude (mV)

23 ± 4.1 (14)

34 ± 3.5 (24)

1^st spike threshold (mv)

−32.4 ± 0.8 (14)

−35.1 ± 1.0 (24)

1^st spike width (msec)

4.4 ± 0.5 (14)

2.9 ± 0.3 (24)^a

10 Hz 1^st latency (msec)

44 ± 3.2 (14)

37 ± 2.0 (24)

10 Hz 1^st frequency (Hz)

11 ± 0.3 (14)

12 ± 0.3 (24)^a

10 Hz frequency adaptation

1.2 ± 0.04 (14)

1.3 ± 0.05 (24)

10 Hz after potential (mv)

0.9 ± 0.5 (14)

−0.9 ± 0.7 (24)

f-I slope 1^st interval

0.59 ± 0.07 (14)

0.44 ± 0.03 (24)

f-I slope average frequency

0.54 ± 0.07 (14)

0.36 ± 0.03 (24)

Sag at −90 mV (mV)

3.3 ± 1.1 (14)

3.3 ± 0.7 (24)

Peak I Na (nA)

−1.06 ± 0.12 (40)

−2.09 ± 0.16 (58)^a

Vm for peak I Na (mV)

−21.0 ± 1.6 (40)

−26.1 ± 1.4 (58)^a