Fig. 4

Relative mRNA expression levels of pro- and anti-apoptosis-associated genes in mono- and co-cultured hepatocytes. a BCL-2, b BAX, c BAX/BCL-2 ratio, d BID, e BLK and f CASP9. Values are mean ± standard deviation (n = 6). **p <0.01, versus hepatocyte mono-culture; ^§§ p <0.01, versus co-culture; ^{^^} p <0.01, versus SS-treated, mono-cultured hepatocytes; ^## p < 0.01, versus co-culture with NPc-MSCs; ⁺ p < 0.05 and ⁺⁺ p < 0.01, versus co-culture with HPc-MSCs. BAX Bcl-2-associated X protein, BCL-2 B-cell lymphoma 2, BID BH3 interacting-domain death agonist, BLK B lymphoid tyrosine kinase, CASP Caspase, Co Co-culture, HPc Hypoxia-preconditioned, ind. Indirect, NAC N-acetylcysteine, NPc Normoxia-preconditioned, SS Staurosporine