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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model

Fig. 6

a and b Bone marrow derived MSC showing oxygen consumption rate (OCR) in percentage in normal glucose (NG, squares) and high glucose (HG, triangles) using SeaHorse. a shows better OCR in MSCs cultured in NG compared to MSCs cultured in HG, at day 7 of culture. Additives marked with arrows, A: 1nM rPFO, B: 10 mM glutamate and malate +2uM FCCP (Complex-I substrate), c 10 mM succinate (Complex-II substrate). b the experiment has been repeated with prior SOD2 upregulation in HG exposed cells, showing SOD2 upregulation did improve mitochondrial respiration, compared to the panel on left

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Stem Cell Research & Therapy

ISSN: 1757-6512