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Table 3 Effects of mesenchymal stem cells derived from bone marrow and adipose tissue on nerve fibre density in TNBS-induced colitis

From: Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis

  Sham TNBS TNBS + BM-MSC TNBS + AT-MSC
  Level of CGRP immunoreactivity/1 mm2 (%)
24 h 12.0 ± 0.1 6.3 ± 0.6 †††† 9.5 ± 0.5 *** †† 8.5 ± 0.4 * †††
72 h 12.2 ± 0.4 6.1 ± 0.4 †††† 9.6 ± 0.7 *** †† 9.4 ± 0.3 *** ††
  Density of TH-IR nerve fibres/1 mm2 (%)
24 h 17.2 ± 0.8 11.6 ± 0.4 †† 17.4 ± 0.1 ** 16.8 ± 0.9 **
72 h 17.4 ± 1.1 12.6 ± 0.4 †† 17.0 ± 1.3 * 17.5 ± 1.2 **
  Density of VAChT-IR nerve fibres/1 mm2 (%)
24 h 19.9 ± 0.9 11.6 ± 0.8 †††† 20.3 ± 0.5 **** 19.9 ± 0.2 ****
72 h 20.5 ± 1.1 12.9 ± 0.4 †††† 19.6 ± 0.7 **** 20.0 ± 0.6 ****
  1. TNBS 2,4,6-trinitrobenzene sulfonic acid, BM-MSC bone marrow derived mesenchymal stem cells, AT-MSC adipose tissue derived mesenchymal stem cells, CGRP calcitonin gene-related peptide, TH tyrosine hydroxylase, VAChT vesicular acetylcholine transporter, IR immunoreactive
  2. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, significantly different to TNBS; ††p < 0.01, †††p < 0.001, ††††p < 0.0001, significantly different to sham