Table 2 Main achievements in myocardial infarction recovery after the administration of a fibrin scaffold
From: In vivo experience with natural scaffolds for myocardial infarction: the times they are a-changin’
Scaffold material | Cell lines and/or other components | MI model | Main results | References |
|---|---|---|---|---|
Fibrin | Rat skeletal myoblasts | Rat | FS and infarct wall thickness preservation | [52] |
|  | Rat skeletal myoblasts | Rat | Infarct scar size↓, arteriole density↑ | [53] |
|  | Human cardiac and subcutaneous ATDPCs | Mouse | CM and EC differentiation, vessel density↑, LV EF↑, infarct size↓ | [55] |
|  | Rat bone marrow cells | Rat | Cell retention↑, LV perimeter↓, stroke volume and contractility preservation, cardiac function↑ | [56] |
|  | hESCs | Mouse and pig | Cardiac function↑, cell engraftment↑, angiogenesis↑, EF↑, infarct size↓, LV hypertrophy↓, systolic LV wall stress↓, LV systolic thickening fraction↓ | [57] |
|  | Rat adipose-derived MSCs | Rat | Preserved wall thickness, LV end-diastolic and systolic dimensions↓, LV end-diastolic volume↓, LV end-systolic volume↓, LV remodeling suppressed | [58] |
|  | hESC-derived cardiac progenitors | Rat | LV end-systolic volume↓, EF↑, angiogenesis↑, absence of teratomas | [59] |
|  | Human iPSC-derived CMs, ECs, and smooth muscle cells | Pig | Cell survival↑, LV EF↑, contractility↑, infarct size↓, regional wall stress↓, energetic efficiency↑, lack of arrhythmias, apoptosis↓, cellular expression of Nkx2.5↑, angiogenesis↑, immune response delayed, protective paracrine effects | [54] |
|  | Rat heart cells; native population or CM-depleted population | Rat | EF and FS↑ (only for patch with native cell population), wall thickness↑, infarct size↓, cell migration, vascularization↑, electrical coupling and alignment not achieved | [60] |
|  | Human umbilical cord blood MSCs | Mouse | Infarct size↓, vessel density↑ | [61] |
|  | Human umbilical cord blood MSCs | Mouse | Microvasculature formation↑, FS↑, EF↑ | [62] |
|  | Swine MSCs | Pig | LV thickness fraction↑, neovascularization↑, differentiation into myocyte-like cell lineage | [63] |
|  | Swine MSCs+thymosin β4 | Rat | Proliferation↑, protection against hypoxia, LV EF↑, LV FS↑, wall thickening↑, vasculogenesis↑, cell survival↑ | [64] |
Fibrin+PEG | SDF-1α | Mouse | c-kit+ cell recruitment↑, LV function↑ | [68] |
Fibrin+decellularized myocardial ECM | Human mesenchymal progenitor cells (TGF-β-conditioned or not) | Rat | Angiogenesis↑, cell migration↑, LV diameter and area preservation, contractility↑ | [70] |