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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Progenitor-like cells derived from mouse kidney protect against renal fibrosis in a remnant kidney model via decreased endothelial mesenchymal transition

Fig. 4

MKPC injection decreases the recruitment of inflammatory cells and promotes proliferating tubule cells in five-sixths nephrectomized mice. aj Representative photomicrographs illustrate F4/80 and α-SMA expression in the renal tissue of mice receiving saline or MKPC 14 and 17 weeks after five-sixths nephrectomy. Lower numbers of F4/80-positive cells ae (arrow) and α-SMA-positive cells fj (arrow) accumulate in the interstitium of mice treated with MKPCs compared with those injected with saline. km Ki67-positive cells (arrow) are more frequently found in the cortical tubules in mice receiving MKPC injection 14 weeks after chronic kidney injury. Scale bar: 50 μm. *P <0.05, MKPC-treated vs. saline-treated group. Data presented as mean ± SD. α-SMA alpha-smooth muscle actin, MKPC mouse kidney progenitor-like cells, Saline five-sixths nephrectomized mice treated with saline, wk weeks

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