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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine

Fig. 5

Clinical qualitative assessments of periodontal and bone tissues regenerated with dissociated cells and cellular sheet transplantations in miniature pigs. a, b Clinical assessments of the periodontal tissues. At week 0, there was no significant difference in a PD or b AL among the five groups. At 12 weeks post transplantation, the PD and AL were significantly improved in the groups that received an hDPSC injection, HGF-hDPSC injection, hDPSC sheet, or HGF-hDPSC sheet, compared with those in the control group (untreated) (*P <0.01, n = 8). c Bone regeneration height was greatest in the HGF-hDPSC sheet group, but bone regeneration heights were greater in all treatment groups compared with the control group (*P <0.01). The bone regeneration heights in the hDPSC sheet and HGF-hDPSC sheet groups were greater than those in the hDPSC injection (Δ P <0.01) and in the HGF-hDPSC injection (# P <0.01) groups. d Bone regeneration volume was largest in the HGF-hDPSC sheet group. Bone regeneration volumes in the hDPSC injection, HGF-hDPSC injection, and hDPSC sheet groups were also larger than that in the control group (*P <0.01). Bone regeneration volumes were larger in the hDPSC sheet and HGF-hDPSC sheet groups than in the hDPSC injection group (Δ P <0.01). Bone regeneration volumes were larger in the hDPSC sheet and HGF-hDPSC sheet groups compared with the HGF-hDPSC injection group (# P <0.01). hDPSC human dental pulp stem cell, HGF hepatocyte growth factor, w weeks

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Stem Cell Research & Therapy

ISSN: 1757-6512