Fig. 2

Oct3/4 is required for c-kit⁺ CSC transplantation to improve impaired LV function in post-MI mice. Echocardiographic measurements of LV functional parameters: left ventricular internal dimension in diastole (LVID;d) (a), left ventricular internal dimension in systole (LVID;s) (b), ejection fraction (EF) (c), and fractional shortening (FS) (d). Representative M-mode images (e). Data shown as mean ± SEM (n = 5 per group). ***p <0.001 vs. sham, **p <0.01 vs. sham, #p <0.05 vs. MI + CSCs-Oct3/4 (+) control siRNA, ##p <0.01 vs. MI + CSCs-Oct3/4(+) control siRNA. CSC cardiac stem cell, MI myocardial infarction, PBS phosphate-buffered saline, siRNA small interfering RNA