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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Inhibition of Oct 3/4 mitigates the cardiac progenitor-derived myocardial repair in infarcted myocardium

Fig. 5

Inhibition of Oct3/4 attenuated the capacity of CSCs to prevent MI-induced cardiac hypertrophy and remodeling. a Representative images of Masson’s trichrome-stained myocardial left ventricle in MI hearts receiving c-kit+ CSC transplantation and PBS injection. Scale bar: 100 μm. b Quantitative analysis of myocardium infarct size. c Representative images of WGA staining in post-MI mouse hearts. Scale bar: 100 μm. d Quantitative analysis of myocyte cross-sectional area. Data shown as mean ± SEM (n = 3–5 per group). &p <0.05 vs. sham, *p <0.05 vs. MI-PBS, #p <0.05 vs. MI + CSCs-Oct3/4(+) control siRNA. CSC cardiac stem cell, LV left ventricular, MI myocardial infarction, PBS phosphate-buffered saline, siRNA small interfering RNA

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