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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway

Fig. 5

MSC-secreted HGF restored endothelial F-actin remodelling. LPS cause “actin stress fibre” formation in HPMEC, which is the movement of actin from the cortical rim to a disorganized intracellular fashion. It is this stress fibre formation which causes the cells to contract, increasing paracellular permeability. After 24 h of MSC-CM and HPMEC co-culture, actin stress fibre was partially restored. However, neutralising HGF from the MSC-CM with anti-HGF antibody caused actin stress fibre formation again. Adding MSC-CM in all groups except control group and LPS group. CM Conditioned medium, HGF Hepatocyte growth factor, LPS Lipopolysaccharide, MSC Mesenchymal stem cell, VEGF Vascular endothelial growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512